Evaluation of membranes of copolypeptide of γ-benzyl l-glutamate and l-glutamic acid for the permeability of anticancer drugs

Autor:	Yue-E Fang, Wei-Dong He, Tian-Yi Shi
Rok vydání:	1997
Předmět:	Chemistry Glutamate receptor Filtration and Separation Glutamic acid Permeation Biochemistry Dosage form Membrane Permeability (electromagnetism) Copolymer Organic chemistry heterocyclic compounds General Materials Science Physical and Theoretical Chemistry Saponification Nuclear chemistry
Zdroj:	Journal of Membrane Science. 130:17-21
ISSN:	0376-7388
DOI:	10.1016/s0376-7388(97)00021-5
Popis:	The membranes of poly(γ-benzyl l -glutamate-co- l -glutamic acid) [P(BLG-LGA)] were prepared by saponification of poly(γ-benzyl l -glutamate) (PBLG) membranes. The permeation of two anticancer drugs, 5-fluoro-uracil (5-fu) and 2-hydroxyethyl-oxy-methyl-5-fluoro-uracil (2-HEOM-5-Fu), through these membranes was studied. The results showed a sharp increase in permeability of the copolymer membranes compared to the PBLG membranes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::01f7452062f6e4667902c509840bde7b https://doi.org/10.1016/s0376-7388(97)00021-5 Zobrazit plný text záznamu Full Text from ScienceDirect