Detection of integrins using surface-enhanced Raman spectroscopy

Autor:	Gerald A. Meininger, V. Alexander Gant, Mustafa Habib Chowdury, Gerard L. Coté
Rok vydání:	2004
Předmět:	biology Atomic force microscopy Chemistry Integrin Nanotechnology Adhesion Surface-enhanced Raman spectroscopy Fibronectin Extracellular matrix symbols.namesake SILVER COLLOIDAL symbols biology.protein Raman spectroscopy
Zdroj:	Optical Diagnostics and Sensing IV.
ISSN:	0277-786X
DOI:	10.1117/12.535344
Popis:	Integrins play an important role in the adhesion of cells to extracellular matrix and to other cells around them, more specifically fibronectin. The ultimate goal of this research is to detect these integrins on the surface of the cell with a combined atomic force microscopy (AFM) system coupled with a surface enhanced Raman spectroscopy (SERS) system. For this paper the focus was on identifying whether SERS is capable of being used to generate a unique spectrum for integrins. This was done using silver colloidal particles and the integrins a5B1 and aVB3. It was shown that a unique spectrum could be identified for each of these integrins at the nanomolar level.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::01f563b6258d6395f93fae6db54c6a87 https://doi.org/10.1117/12.535344 Zobrazit plný text záznamu