Odor conditioning with morphine: Conditioned preference, aversion, and analgesia
| Autor: | J. M. Valone, Philipp J. Kraemer, Christopher K. Randall, Michael T. Bardo |
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| Rok vydání: | 1993 |
| Předmět: |
Communication
Physiology business.industry musculoskeletal neural and ocular physiology General Neuroscience Analgesic Classical conditioning Olfaction Stimulus (physiology) Odor Preference test Anesthesia Morphine medicine Conditioning business Psychology psychological phenomena and processes medicine.drug |
| Zdroj: | Psychobiology. 21:215-220 |
| ISSN: | 0889-6313 |
| DOI: | 10.3758/bf03327137 |
| Popis: | The dose-dependent effects of morphine on odor conditioning in rats were examined in two experiments. Subjects received one odor paired with either a low dose of morphine (0.5 mg/kg; Experiment 1A) or a high dose of morphine (10.0 mg/kg; Experiment 1B), alternating with another odor paired with saline. In Experiment 1A, subjects spent significantly more time over the morphine-paired odor than over the saline-paired odor in a spatial-odor preference test (odor preference). In Experiment 1B, subjects spent significantly less time over the morphine-paired odor than over the saline-paired odor (odor aversion). In Experiment 2, pairing an odor with a high dose of morphine (10.0 mg/kg) produced a conditioned analgesic response, measured by paw-lick latency. These studies demonstrate that an odor may serve as an effective stimulus to which the motivational and analgesic effects of morphine can be conditioned. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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