Anticorps sériques contre le virus de l'hépatite C : étude de 4 100 donneurs de sang du nord-est de la France
| Autor: | J.C. Humbert, C. Tamisier, M. Billuart, Streiff F, C. Janot, J.P. Aymard, J.C. Adjizian |
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| Rok vydání: | 1990 |
| Předmět: |
Hepatitis B virus
Gynecology medicine.medical_specialty biology business.industry Hepacivirus Hepatitis C virus virus diseases General Medicine Hepatitis C medicine.disease biology.organism_classification medicine.disease_cause digestive system diseases Hepadnaviridae Alanine transaminase medicine biology.protein Antibody Alanine aminotransferase business |
| Zdroj: | Revue Française de Transfusion et d'Hémobiologie. 33:295-302 |
| ISSN: | 1140-4639 |
| Popis: | Between June 1989 and February 1990 the prevalence of antibodies to hepatitis C virus (anti-HCV) was studied in blood donations from 4,100 donors tested in north east France. 37 samples were found reactive for anti-HCV (prevalence of anti-HCV: 0.90%) without any significant difference in sex (males: 0.94%; females: 0.87%) and age distributions. 178 (4.34%) of the 4,100 donors were found anti-HBc positive, 5 of these donors being anti-HCV positive (13.51% of all anti-HCV positive donors). 52 donors (1.27%) had raised alanine aminotransferase (ALT) levels (greater than or equal to 2 N: 2 times the M +/- 2 SD value): 3 were found anti-HCV positive (8.11% of all anti-HCV positive donors). Association of the 2 surrogate markers is poorly sensitive since it detects only 8 (21.62%; males: 4, females: 4) of all anti-HCV positive donors. Furthermore, it appears weekly specific since it discards 230 blood samples of which 222 (96.52%) were anti-HCV negative. The 2 surrogate markers are complementary to one another and none of the anti-HCV positive donors had both anti-HBc antibodies and raised ALT. The mean ALT level is significantly higher in anti-HCV positive donors as compared to seronegative (M +/- 1 SD: 51 +/- 82 U/l versus 24 +/- 17 U/l). In anti-HCV positive donors, a marginal (r = 0.34) though statistically significant (p less than 0.05) positive correlation was found between ALT level and anti-HCV ratio.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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