Syntheses of Dexamethasone Conjugates of the Phytohormones Gibberellin A3 and 24-Epicastasterone

Autor:	Adelheid Kolbe, Guenter Adam, Robert Kramell, Jürgen Schmidt, Andrea Porzel, Gernot Schneider
Rok vydání:	2002
Předmět:	chemistry.chemical_compound chemistry Hexafluorophosphate 24-epicastasterone Amine gas treating Gibberellin General Chemistry Oxime Medicinal chemistry Gibberellic acid Conjugate
Zdroj:	Collection of Czechoslovak Chemical Communications. 67:103-114
ISSN:	1212-6950 0010-0765
Popis:	The syntheses of N-[10-(9α-fluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxamido)decyl]gibberellamide (7) and 6-[({N-[10-(9α-fluoro-11β,17α-dihydroxy- 16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxamido)decyl]carbamoyl}methoxy)imino]-24-epicastasterone (10) are described. [(Benzotriazol-1-yl)oxy]bis(pyrrolidin-1-yl)methylium hexafluorophosphate (HBPyU) was used as the coupling agent for the reaction of gibberellic acid as well as of 24-epicastasterone-O-(carboxymethyl)oxime with N-(10-aminodecyl)- 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxamide (4). The gibberellic acid conjugate 7 was also synthesised by the coupling of succinimidyl gibberellate 6 with amine 4.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::01e03083e295e4a23c04f984ef2abbd1 https://doi.org/10.1135/cccc20020103 Zobrazit plný text záznamu