An iterative synthesis of radiolabelled polyethylene glycol oligomers
| Autor: | Jon F. Denissen, Hugh N. Nellans, Robert G. Maki, Joseph F. Dellaria, Francis A. J. Kerdesky, Daniel J. Hoffman |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Olefin fiber
Ozonolysis Sodium Organic Chemistry technology industry and agriculture chemistry.chemical_element Polyethylene glycol Biochemistry Oligomer Analytical Chemistry chemistry.chemical_compound chemistry Drug Discovery Polymer chemistry PEG ratio Radiology Nuclear Medicine and imaging Tritium Ethylene glycol Spectroscopy |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 27:1437-1450 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580271211 |
| Popis: | A synthetic method has been developed for the iterative preparation of unlabelled and 3H-polyethylene glycol (PEG) oligomers. The strategy involved alkylating the sodium anion of mono-tritylated ethylene glycol oligomers (Ph3C[OCH2CH2]nOH, n=1−28) with O-tosyl-O-allyl-triethylene glycol or O-tosyl-O-allyl-pentaethylene glycol. Subsequent ozonolysis of the terminal olefin followed by reduction with NaBH4 or NaB[3H]4 provided the next higher mono-tritylated ethylene glycol oligomer which could be deprotected to the final glycol oligomer (H[OCH2CH2]nOH, n=4−34) or carried on in the iterative process. The method provides discrete PEG oligomers of high specific activity (20.6–48.6 mCi/mmoL) in 96–98% radiochemical purity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text