Structural and dynamic characterization of solid furosemide polymorphs by NQR and NMR methods

Autor:	Claudia Garnero, Mariano Zuriaga, Marcela Raquel Longhi, S. C. Perez, J. Abraham Miranda, Sonia Nerina Faudone, Alberto Wolfenson
Rok vydání:	2015
Předmět:	Proton Chemistry Relaxation (NMR) Analytical chemistry General Physics and Astronomy Furosemide Characterization (materials science) Crystallography Phase (matter) medicine Physical and Theoretical Chemistry Conformational isomerism Line (formation) medicine.drug
Zdroj:	Chemical Physics Letters. 641:163-168
ISSN:	0009-2614
DOI:	10.1016/j.cplett.2015.10.066
Popis:	The temperature dependence of NQR parameters and proton spin–lattice relaxation times of furosemide in forms 1 and 2 are reported. The NQR line shape shows that form 2 is disordered, even at low temperatures and reorientation of the SO2NH2 group between conformers has been detected above 120 K. Through T1H measurements a transition of form 2 to the high temperature phase of furosemide is observed around 405 K. The high temperature phase is characterized by one NQR line indicating Z′ = 1 in this phase. Proton transfer and NH2 jumps in form 1 are also observed through T1Q measurements.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::01d76c63d03ad6b8ff880622620b5580 https://doi.org/10.1016/j.cplett.2015.10.066 Zobrazit plný text záznamu Full Text from ScienceDirect