Chemoresistant hepatoblastoma in a patient with mosaic trisomy 18 treated with orthotopic liver transplantation
| Autor: | Karen S. Fernández, Lars M. Wagner, Mike A. Leonis, Greg Tiao, Bonita Fung, Rebecca Baum, Mary Elizabeth Ross, Nicholas D. Yeager |
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| Rok vydání: | 2010 |
| Předmět: |
Cisplatin
Hepatoblastoma Pathology medicine.medical_specialty Vincristine Chemotherapy business.industry medicine.medical_treatment Hematology Liver transplantation medicine.disease digestive system diseases Transplantation Oncology Fluorouracil Pediatrics Perinatology and Child Health medicine business Trisomy medicine.drug |
| Zdroj: | Pediatric Blood & Cancer. 56:498-500 |
| ISSN: | 1545-5009 |
| Popis: | We present a 9-month-old male with mosaic trisomy 18 with a right hepatic lobe mass. The tumor was completely resected and identified as pure fetal histology hepatoblastoma but contained increased mitotic activity. Adjuvant chemotherapy consisted of cisplatin, vincristine, and 5-fluorouracil. After the first and fourth cycles of chemotherapy, recurrent tumor developed. The patient underwent rescue orthotopic liver transplantation, and is currently alive without evidence of hepatoblastoma 28 months after transplantation. This report demonstrates the use of orthotopic liver transplantation in a child with mosaic trisomy 18 and hepatoblastoma. |
| Databáze: | OpenAIRE |
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