Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer
| Autor: | Gypsyamber D'Souza, Tarik Gheit, Christine Carreira, Victor Wünsch-Filho, Sandrine McKay-Chopin, Massimo Tommasino, Wolfgang Ahrens, Gabriella Cadoni, José Eduardo Levi, Eloiza H. Tajara, Franco Merletti, Devasena Anantharaman, Daniel C. Beachler, Stefania Boccia, Kathy Wisniewski, David I. Conway, Priscilia Chopard, Tatiana Natasha Toporcov, Andrew F. Olshan, Behnoush Abedi-Ardekani, Guido Rindi, Raquel Ajub Moyses, Paul Brennan, Ghislaine Scelo, Sylvia Wright, Helene Renard |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Larynx Cancer Research medicine.medical_specialty Laryngeal Cancers business.industry Head and neck cancer Sample processing Oral cavity medicine.disease 03 medical and health sciences Hpv testing 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine medicine Etiology Human papillomavirus business |
| Zdroj: | International Journal of Cancer. 140:1968-1975 |
| ISSN: | 0020-7136 |
| Popis: | Human papillomavirus (HPV) causes oropharyngeal squamous cell carcinoma (OPSCC), although strongly divergent results have been reported regarding the prevalence of HPV16 in different countries, whether this represents important differences in etiology remains unclear. Applying rigorous protocols for sample processing, we centrally evaluated 1420 head and neck tumors (533 oropharynx, 395 oral cavity and 482 larynx) from studies conducted in the US, Europe and Brazil for mucosal HPV DNA and p16INK4a expression to evaluate regional heterogeneity in the proportion of HPV16-associated OPSCC and other head and neck cancer, and to assess covariates associated with the risk of HPV16-positive OPSCC. While majority of OPSCC in the US (60%) were HPV16-positive, this proportion was 31% in Europe and only 4% in Brazil (p |
| Databáze: | OpenAIRE |
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