2-Arylbenzothiazoles: Advances in Anti-Cancer and Diagnostic Pharmaceuticals Discovery

Autor:	E. P. Studentsov, Raisa Krasikova, V. I. Krutikov, A. A. Golovina, D. D. Vaulina, V. V. Orlovskaja, S. M. Ramsh
Rok vydání:	2021
Předmět:	Antiproliferative Drugs 010405 organic chemistry Chemistry medicine Future application Cancer General Chemistry Computational biology 010402 general chemistry medicine.disease 01 natural sciences 0104 chemical sciences
Zdroj:	Russian Journal of General Chemistry. 91:1-33
ISSN:	1608-3350 1070-3632
Popis:	This review summarizes and analyzes published medicinal chemistry data regarding physiologically active 2-arylbenzothiazoles – a promising class of antiproliferative agents and potential diagnostic agents for Alzheimer’s disease. The data have been examined in the light of SAR approach to the properties of 2-arylbenzothiazoles and substances bioactivation mechanisms using labeled radiopharmaceuticals. The most promising leaders-in-class for which clinical trials have been recommended or conducted have been highlighted. Synthetic methods for the preparation of 2-arylbenzothiazoles as precursors of new-generation drugs have been analyzed in detail. Various methods for the preparation of fluorine-containing 2-arylbenzothiazoles, including synthetic pathway to antiproliferative drugs PMX 610, 5-F 203, and Phortress have been described. 2-Arylbenzothiazoles future application in biology and medicine has been discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::01a3f3e4baadb5c4bba19dce006de978 https://doi.org/10.1134/s1070363221010011 Zobrazit plný text záznamu Plný text ve formátu PDF