2-Arylbenzothiazoles: Advances in Anti-Cancer and Diagnostic Pharmaceuticals Discovery
Autor: | E. P. Studentsov, Raisa Krasikova, V. I. Krutikov, A. A. Golovina, D. D. Vaulina, V. V. Orlovskaja, S. M. Ramsh |
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Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Russian Journal of General Chemistry. 91:1-33 |
ISSN: | 1608-3350 1070-3632 |
Popis: | This review summarizes and analyzes published medicinal chemistry data regarding physiologically active 2-arylbenzothiazoles – a promising class of antiproliferative agents and potential diagnostic agents for Alzheimer’s disease. The data have been examined in the light of SAR approach to the properties of 2-arylbenzothiazoles and substances bioactivation mechanisms using labeled radiopharmaceuticals. The most promising leaders-in-class for which clinical trials have been recommended or conducted have been highlighted. Synthetic methods for the preparation of 2-arylbenzothiazoles as precursors of new-generation drugs have been analyzed in detail. Various methods for the preparation of fluorine-containing 2-arylbenzothiazoles, including synthetic pathway to antiproliferative drugs PMX 610, 5-F 203, and Phortress have been described. 2-Arylbenzothiazoles future application in biology and medicine has been discussed. |
Databáze: | OpenAIRE |
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