| Autor: |
E. Alex Pariente, Faouzi Saliba, Didier Samuel, Sylvie Marion, Henri Bismuth, Jean-Pierre Benhamou, Jacques Bernuau, François Durand |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Journal of Hepatology. 15:144-146 |
| ISSN: |
0168-8278 |
| Popis: |
Fipexide belongs to a new class of cognition activators and is noted for its lack of amphetamin-like side effects. We describe three patients who developed fulminant hepatic failure less than 2 months after beginning fipexide administration. The mean interval from the onset of jaundice to the onset of encephalopathy was 8 days. Emergency liver transplantation was undertaken when factor V was 20% of normal or less and coma developed. All patients were transplanted less than 1 week after the onset of encephalopathy. Two survived and one died immediately after transplantation. Histologic examination of the livers revealed massive liver cell necrosis, predominantly centrilobular, and a moderate inflammatory infiltrate within the portal spaces. We conclude that fipexide can induce massive liver cell necrosis and fulminant liver failure. As a result of this life-threatening complication, reconsideration of the indications for this drug is warranted. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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