First-line patterns of care and outcomes of HER2-positive breast cancer patients who progressed after receiving adjuvant trastuzumab in the outpatient community setting
| Autor: | Clara Chen, M. T. Forsyth, M. Shing, D. Lalla, J. F. Doan, S. K. Gruschkus |
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| Rok vydání: | 2010 |
| Předmět: |
Oncology
Patterns of care Cancer Research medicine.medical_specialty Proportional hazards model business.industry medicine.medical_treatment Retrospective cohort study medicine.disease Surgery Breast cancer Trastuzumab Internal medicine HER2 Positive Breast Cancer Cohort medicine business Adjuvant medicine.drug |
| Zdroj: | Journal of Clinical Oncology. 28:684-684 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2010.28.15_suppl.684 |
| Popis: | 684 Background: Trastuzumab (T) is indicated in the adjuvant and first-line setting for HER2+ breast cancer patients (pts). The purpose of this retrospective study was to evaluate community-based patterns of care and outcomes following disease progression (DP) among pts who received T in the adjuvant setting. Methods: Using US Oncology's iKnowMed EMR data, we identified adjuvant HER2+ pts who received T from 1/1/2006–7/31/2007. Pts were followed through 8/31/2009 to observe DP and post-progression patterns of care and outcomes. Pts who experienced DP were assigned to cohorts based on whether they received T in the first-line setting. Overall (OS) and progression-free survival (PFS) were compared by cohort using Kaplan-Meier and Cox regression analysis. To account for survivorship bias, landmark analyses were conducted at 120 and 180 days to examine residual PFS and OS, defined as time from landmark to DP or death. Results: Of 2,049 pts who received adjuvant T, 164 (8%) experienced DP and received first-li... |
| Databáze: | OpenAIRE |
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