Novel MYH7 mutation associated with mild myopathy but life-threatening ventricular arrhythmias and noncompaction
| Autor: | Oliver Brandau, Katharina Bichler, Franco Laccone, Josef Finsterer, Claudia Stöllberger, Nigel G. Laing |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Cardioprotection
medicine.medical_specialty biology Cath lab business.industry medicine.medical_treatment Ischemia Implantable cardioverter-defibrillator medicine.disease Troponin Internal medicine Conventional PCI biology.protein Cardiology Medicine MYH7 medicine.symptom Cardiology and Cardiovascular Medicine business Myopathy |
| Zdroj: | International Journal of Cardiology. 173:532-535 |
| ISSN: | 0167-5273 |
| Popis: | demonstrated PMI reduction using RIPC [3–5,7–9], however two studies have produced discrepant results [6,10]. A possible explanation may be that to implement RIPC in a busy cath lab,wheremost PCIs are conducted ad hoc, Prasad et al. used 3 cycles of 3-minute ischemia/3 minute reperfusion [10]. Since animal models have shown that cardioprotection depends on the duration of transient ischemia, one may hypothesize that 3-minute ischemia was not a sufficient ischemic stimulus to elicit cardioprotection. In the study by Iliodromitis et al., using a Z-test it can be easily calculated that all patients in the RIPC group and 82% of patients in the control group had post-procedural troponin N5 times the mean baseline value (0.04 ng/mL), suggesting that perhaps due to analytical issues, their results may not be directly comparable [6]. In conclusion, the pooled analysis of all available studies suggests that RIPCbefore elective PCI is effective in reducing PMI. Even though thismay notbeequivalent to the reductionofmajor adverse cardiovascular events, RIPC is simple to apply, non-invasive, and virtually cost-free and could be incorporated into clinical practice. |
| Databáze: | OpenAIRE |
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