Immunologic mechanisms in allergic cutaneous vasculitis: cellular interactions, effects of cytokines, therapeutic insights*

Autor: J.D. Stratigos, A.D. Tosca
Rok vydání: 1992
Předmět:
Zdroj: Journal of the European Academy of Dermatology and Venereology. 1:179-186
ISSN: 1468-3083
0926-9959
DOI: 10.1111/j.1468-3083.1992.tb00630.x
Popis: After establishment of the importance of circulating and tissue bound immune complexes in the immunopathogenesis of allergic cutaneous vasculitis, endothelial cell cultures and the development of experimental models permitted us to further visualise aspects of cell-cell interactions, inflammatory mediators and recently studied adhesion molecules, knowledge that might lead to deeper comprehension of the immunology of vasculitis and at the same time open new horizons for therapeutic intervention. In this review, recent data concerning immunologic mechanisms in allergic cutaneous vasculitis are presented. Emphasis is given to anti-idiotypic antibodies, monocyte-endothelial cell, neutrophil-endothelial cell and lymphocyte-endothelial cell interactions. The implication of cytokines in immune complex mediated inflammation is postulated. Therapeutic attempts with anti-idiotypic antibodies, cytokine inhibitors or antagonists and monoclonal antibodies against cell surface leukocyte or endothelial molecules might be rewarding in the future.
Databáze: OpenAIRE
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