| Popis: |
Adult neurogenesis in the dentate gyrus is profoundly disrupted by seizure activity in experimental models. The relationship between this disruption, seizure-induced plasticity, and the pathogenesis of epilepsy is complex and not well understood, but there is great interest in the therapeutic potential of modulating the effects of seizures on dentate granule cell (DGC) neurogenesis. In this chapter, we discuss how seizure activity or epileptic insults influence DGC neurogenesis, as well as the potential effects of altered neurogenesis on epilepsy development, a process known as epileptogenesis. Where possible, data are included that provide insight into potential underlying mechanisms, or to highlight specific areas where more work is needed to better understand the relationship between seizure activity and aberrant neurogenesis. |
