Scant Reliability of Co/Ct Ratio in Urea Kinetic Formulas
| Autor: | Alloatti S, Bonfant G, Gaiter Am, Torazza Mc, Bosticardo Gm, Nebiolo Pe, Gabella P |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_treatment
030232 urology & nephrology Biomedical Engineering Analytical chemistry Medicine (miscellaneous) Bioengineering General Medicine 030204 cardiovascular system & hematology Kinetic energy Biomaterials Clinical Practice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry medicine Urea Experimental work Hemodialysis |
| Zdroj: | The International Journal of Artificial Organs. 12:642-647 |
| ISSN: | 1724-6040 0391-3988 |
| DOI: | 10.1177/039139888901201008 |
| Popis: | The ratio initial/final urea value is used in urea kinetic formulas. To assess its reliability we employed mass balances and urea clearances to study 15 hemodialysis treatments divided in several parts. The mass balances clearly indicated urea disequilibrium. In the first phases of dialysis, urea extraction, measured by dialysate collection, was lower than the corresponding change in urea pool, whereas in the later phases the opposite occured. On account of this lack of equilibrium, clearances bases on the Co/Ct ratio (K2) are less reliable than standard clearances derived from total dialysate collection (K1): in the first quarter of dialysis, K2 is greater than K1 (p< 0.01), while in the 3rd and 4th quarters it is lower. The comparison of clearances in a cumulative way showed a significant fall in K2 (p< 0.01) while K1 remained stable. From a practical point of view, aberrations induced by non monocompartmental urea behaviour are negligible, and do not invalidate the usefulness of the single-pool Gotch model in clinical practice. However, at least in experimental work, the limits of urea kinetic formulas must be taken into account. |
| Databáze: | OpenAIRE |
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