Highly anti-selective conjugate addition of arylcuprates to a γ-alkoxy-α,β-enoate. A new method to address stereochemical challenges presented by Amaryllidaceae alkaloids

Autor:	Madhuri Manpadi, Alexander Kornienko
Rok vydání:	2005
Předmět:	Stereochemistry Chemistry Organic Chemistry Drug Discovery Alkoxy group Amaryllidaceae Alkaloids Biochemistry Conjugate
Zdroj:	Tetrahedron Letters. 46:4433-4437
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2005.05.006
Popis:	Various substituted arylcuprates undergo stereocontrolled additions to a d -mannitol-derived γ-alkoxy-α,β-enoate with exclusive anti-selectivity. The method is well suited for the preparation of a broad range of biologically active Amaryllidaceae alkaloids and their aromatic analogues. A model accounting for the stereochemical outcome of this process is presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::01658ea8c449d8b2f06a149deb1c3369 https://doi.org/10.1016/j.tetlet.2005.05.006 Zobrazit plný text záznamu Full Text from ScienceDirect