Significance of tubulointerstitial fibrosis in paediatric IgM nephropathy
| Autor: | Rachanee Sensirivatana, Futrakul P, Jaakchai Jungthirapanich, Vararat Singkhwa, Dhevy Watana, Yenrudi S |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Pathology business.industry medicine.drug_class Group ii General Medicine medicine.disease Gastroenterology Lesion Impaired renal function Nephrology Internal medicine Tubulointerstitial fibrosis IgM nephropathy Medicine Corticosteroid Mesangial proliferative glomerulonephritis medicine.symptom business Paediatric patients |
| Zdroj: | Nephrology. 3:509-514 |
| ISSN: | 1440-1797 1320-5358 |
| Popis: | Summary: The significance of tubulointerstitial fibrosis in paediatric patients with primary diffuse mesangial proliferative glomerulonephritis and IgM deposition (IgM nephropathy) has not been well documented. the clinical course, therapeutic response and final outcome of 35 patients in whom renal biopsies showed IgM nephropathy are reported. They have been subdivided into two groups according to the absence (19 patients: group I) or presence (16 patients: group II) of superimposed lesion of tubulointerstitial fibrosis. Clinical presentation was similar in both groups but the patients in group I were male predominant (2.8:1 vs 1: 1). 6/19 (31.6%) of the patients in group I and 1/16 (6.3%) in group II responded to corticosteroid, 11/19 (57.9%) in group I and 8/16 (50.0%) in group II had steroid dependent, whereas 2/19 (10.5%) in group I and 7/16 (43.7%) in group II had steroid resistant. About 42% of the patients in group I and 94% in group II required cyclophosphamide therapy by which similar response in both groups (approximately 75%) were observed. the steroid non-responders and cyclophosphosphamide therapy among patients in group II were significantly higher (P |
| Databáze: | OpenAIRE |
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