Complement components C3 and C4 levels in Chronic Obstructive Pulmonary Disease (COPD) patients and their correlation with severity of airflow obstruction
| Autor: | Hariom Sharma, Keyur H Madhu, Tejas Shah, Hari S Sharma, Chirag K Pandya |
|---|---|
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | International Journal of Clinical Biochemistry and Research. 6:485-489 |
| ISSN: | 2394-6377 2394-6369 |
| DOI: | 10.18231/j.ijcbr.2019.101 |
| Popis: | Introduction: Although a great deal is known about etiopathogenesis of Chronic Obstructive Pulmonary Disease (COPD), there are still substantial lacunae in comprehending the role of immunity in the part played by recurrent secondary infections occurring in patients with COPD who have been shown to present decreased serum levels of complement components C3 and C4 than healthy subjects. Objectives: Measure and compare the levels of complement C3 and C4 in COPD patients with healthy controls and also correlate their levels with severity of COPD. Materials and Methods: This was a prospective case control study conducted at GMC, Bhavnagar with 75 known cases of COPD patients and 75 controls. Cases were subdivided into three subgroups with Pulmonary Function Test scores. Biochemical investigations from venous blood samples were performed on Mispa i2 specific protein analyzers. Data analysis was done by using unpaired t-test, one-way ANOVA test and post hoc test. Results: In the present study the levels of complement C3 (Case: 142.2347.23, control: 160.4837.77 and p decreased in COPD patients in comparison to healthy subjects. In addition to that C4 levels were significantly decreased in between mild to moderate and mild to severe obstructive COPD cases (p statistically significant (p>0.05). Conclusion: It is suggested from this study that measurement of complement levels may be used to asses severity of obstruction in COPD patients with more emphasis given to C4 levels. Keywords: COPD, C3, C4, Complement activation, PFT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|