Seroprevalence and incidence of transfusion-transmitted infectious diseases among blood donors from regional blood transfusion centres in Burkina Faso, West Africa

Autor: Alice Kiba, Jacques Simpore, Jean Baptiste Nikiema, Mahamoudou Sanou, Jean Didier Zongo, Kisito Kienou, Honorine Dahourou, Yacouba Nébié, Siaka Ouattara, Bolni Marius Nagalo, Remy Moret, Cyrille Bisseye
Rok vydání: 2011
Předmět:
Zdroj: Tropical Medicine & International Health. 17:247-253
ISSN: 1360-2276
Popis: BACKGROUND AND OBJECTIVE: The high prevalence of numerous transfusion-transmitted infectious diseases such as HIV HBV HCV and syphilis in sub-Saharan Africa affects blood safety for transfusion recipients. The aim of this study was to evaluate the prevalence and incidence of transfusion-transmissible infectious diseases among blood donors in Burkina Faso. METHODS: A retrospective study of blood donors records from January to December 2009 was conducted. Prevalence and incidence of viral infections were calculated among repeat and first-time blood donors. RESULTS: Of the total of 31405 first-time volunteer blood donors in 2009 24.0% were infected with at least one pathogen and 1.8% had serological evidence of multiple infections. The seroprevalence of HIV HBV HCV and syphilis in first-time volunteer donors was 1.8% 13.4% 6.3% and 2.1% respectively. In 3981 repeat donors the incidence rate was 3270.2 5874.1 and 6784.6 per 100000 donations for anti-HIV-1 HBsAg and anti-HCV respectively. These numbers varied significantly according to populations where blood is collected and blood centres in Burkina Faso. CONCLUSION: The relatively high prevalence of viral markers in first-time volunteers and remarkably high incidence of infections in repeat donors raise concerns regarding the safety of these donors and suggest that implementation of NAT might significantly improve the situation. (c) 2011 Blackwell Publishing Ltd.
Databáze: OpenAIRE
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