Abstract WP538: Sex Differences in Intracranial and Extracranial Atherosclerosis in Patients With Acute Ischemic Stroke
| Autor: | Marieke J.H. Wermer, Hendrikus J.A. van Os, Ale Algra, Marianne A. A. van Walderveen, Birgitta K. Velthuis, Sabine Voigt, Pim A. de Jong, Alexander Broersen, Irene C. van der Schaaf, Remko Kockelkoren, L.J. Kappelle |
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| Rok vydání: | 2019 |
| Předmět: |
Advanced and Specialized Nursing
medicine.medical_specialty medicine.diagnostic_test business.industry Large population Computed tomography Internal medicine Ischemic stroke Ischaemic stroke Cardiology Medicine In patient Neurology (clinical) Cardiology and Cardiovascular Medicine business Acute ischemic stroke |
| Zdroj: | Stroke. 50 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/str.50.suppl_1.wp538 |
| Popis: | Objective: To investigate sex differences in presence and location of atherosclerosis in a large population of acute ischaemic stroke patients. Methods: Participants were included from the Dutch acute stroke study (DUST), a large prospective multicentre cohort study. All patients received CT/CT-angiography within 9 hours of stroke onset. We assessed the presence of any sign of atherosclerosis in the intra- and extracranial circulation. In addition, we determined the burden of intracranial atherosclerosis by quantifying intracranial internal carotid artery (ICA) calcifications, resulting in calcium volumes. Relative risks between women and men were calculated using multivariable Poisson regression, and adjusted (aRR) for potential confounders (age, hypertension, hyperlipidemia, diabetes, smoking and alcohol use). Results: We included 1397 patients with a mean age of 67 years, of whom 600 (43%) were women. Presence of atherosclerosis in intracranial vessel segments was found as frequently in women as in men (71% versus 72%, aRR 0.95; 95%CI 0.89-1.01). In addition, intracranial ICA calcium volume did not differ between women and men (median volume 124 mm 3 , IQR 35.5-304.5 in women versus 112 mm 3 , IQR 33.0-276.5 in men; tertile largest volume 37% in women versus 33% in men, aRR 1.00; 95% CI 0.95-1.05). Extracranial atherosclerosis was less common in women compared with men (74% vs 81%, aRR 0.86; 95%CI 0.81-0.92). (Table) Conclusions: In patients with acute ischemic stroke the prevalence of intracranial atherosclerosis does not differ between women and men, while extracranial atherosclerosis is less often present in women compared with men. |
| Databáze: | OpenAIRE |
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