Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P1 agonists

Autor:	Lixia Fu, Jeremy Barden, Joel Gatlin, Andrew M. Kawasaki, Minh Le, Jeff Edwards, Hussien A. Al-Shamma, Jayant Thatte, Charles Xing, Yinghong Gao, Moody Jeanne, Michelle Solomon, Sangdon Han, Carleton R. Sage, Thomas O. Schrader, Sheryll Espinola, Luis Lopez, Daniel J. Buzard, Ling Liu, Lars Thoresen, Robert M. Jones
Rok vydání:	2011
Předmět:	Autoimmune disease S1p1 receptor Chemistry Sphingosine-1-phosphate receptor Organic Chemistry Clinical Biochemistry Pharmaceutical Science Butanoic Acids medicine.disease Biochemistry Drug Discovery medicine Molecular Medicine Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 21:6013-6018
ISSN:	0960-894X
Popis:	S1P1 receptor driven lymphopenia has proven utility in the treatment of an array of autoimmune disease states. As a part of our efforts to develop potent and selective S1P1 receptor agonists, we have identified a novel chemical series of 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acid S1P1 receptor agonists.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0116d2d9cbafd603a96e49505c156afd https://doi.org/10.1016/j.bmcl.2011.05.110 Zobrazit plný text záznamu Full Text from ScienceDirect