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The aim of this study was to evaluate the effects of red wine, grape juice or resveratrol consumption on lipid and glycemic profile and liver nuclear area and circularity of Wistar rats submitted to the high fat diet and physical training. Wistar rats, with 90 days, were divided into 5 groups: Control (GC); High Fat (HFG); Grape Juice (GJG); Red Wine (WG) and Resveratrol (RG). The animals performed a running protocol. After 60 days, the animals were anesthetized, blood was collected for biochemical analyzes, sacrificed and the liver removed. Liver samples were mounted on histological slides and stained with hematoxylin and eosin. The results were expressed as mean ± standard deviation and assessed for normality with Kolgomorov-smirnov test. One way ANOVA, and Bonferroni post-test were used. It was considered significant when p |