Neutralization Titres and Vertical HIV-1 Transmission

Autor: C. I. Costa, Beatriz Grinsztejn, Guilherme Amaral Calvet, José Henrique Pilotto, Vera Bongertz, Valdilea G. Veloso, E. C. J. Filho
Rok vydání: 2002
Předmět:
Zdroj: Scandinavian Journal of Immunology. 56:642-644
ISSN: 0300-9475
DOI: 10.1046/j.1365-3083.2002.01174.x
Popis: Replication of the human immunodeficiency virus type 1 (HIV-1) isolate MN in CEM cells was less neutralized by the plasma from the mothers of infected children (MIC) in comparison with the plasma from the mothers of uninfected children (MUC). Significantly higher neutralization titres were observed for the sera from MUCs compared with MICs, and only the sera from MUC showed 100% neutralization of the HIV-1 MN strain. We suggest that a simple neutralization assay as described here could be useful in prognostic analyses.
Databáze: OpenAIRE