Fragmentation behavior of multiple-metal-coordinated acidic oligosaccharides studied by matrix-assisted laser desorption ionization Fourier transform mass spectrometry
| Autor: | Sharron G. Penn, Mark T. Cancilla, Carlito B. Lebrilla |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
chemistry.chemical_classification
Collision-induced dissociation Inorganic chemistry chemistry.chemical_element Oligosaccharide Condensed Matter Physics Alkali metal Fourier transform ion cyclotron resonance Metal Matrix-assisted laser desorption/ionization Fragmentation (mass spectrometry) chemistry visual_art Caesium visual_art.visual_art_medium Physical and Theoretical Chemistry Instrumentation Spectroscopy |
| Zdroj: | International Journal of Mass Spectrometry. :259-269 |
| ISSN: | 1387-3806 |
| DOI: | 10.1016/s1387-3806(99)00169-4 |
| Popis: | Using matrix-assisted laser desorption ionization we have been able to form gas-phase mixed metal complexes by doping acidic oligosaccharides simultaneously with two different alkali metals. Multiple metal coordination brings up several interesting points such as whether the alkali metals act like point charges by repelling one another, and whether the alkali metals bind to specific sites within the saccharide In this work we carried out collision induced dissociation (CID) on multiply coordinated oligosaccharides to gain insight into these questions. By using CID of the mixed metal complexes we find that different alkali metals show differing specificity for whether they bind to the sialic acid containing fragment, or the remaining oligosaccharide fragment. We also find that the sialic acid is not capable of solvating two small alkali metals simultaneously, but for larger alkali metals such as cesium this is not the case. Molecular modeling of acidic sugars show that there is not a “defined” binding site to which the different alkali metals bind, but many local minima exist. |
| Databáze: | OpenAIRE |
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