Austalides, Osteoclast Differentiation Inhibitors from a Marine-Derived Strain of the Fungus Penicillium rudallense
| Autor: | Kyu Hyung Park, Kwang-Jin Kim, Chanyoon Park, Youjung Sung, Weihong Wang, Young-Jin Son, Eunseok Oh, Jusung Lee, Heonjoong Kang |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmaceutical Science
01 natural sciences Analytical Chemistry Phthalide chemistry.chemical_compound Osteoclast Drug Discovery medicine Receptor Pharmacology biology Strain (chemistry) 010405 organic chemistry Activator (genetics) Organic Chemistry Ligand (biochemistry) 0104 chemical sciences 010404 medicinal & biomolecular chemistry medicine.anatomical_structure Complementary and alternative medicine chemistry Biochemistry RANKL biology.protein Molecular Medicine Penicillium rudallense |
| Zdroj: | Journal of Natural Products. 82:3083-3088 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Four new meroterpenoids, austalides V-X (1-3) and a farnesylated phthalide derivative (4), were isolated from the culture of the marine fungus Penicillium rudallense, together with eight known meroterpenoids derivatives (5-12). Their structures, including absolute configurations, were determined by spectroscopic methods. All of the isolated compounds were evaluated for their inhibitory activities on the receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation. Compounds 1, 2, 5-7, and 10 exhibited potent osteoclast differentiation inhibitory activity with ED50 values of 1.9-2.8 μM. |
| Databáze: | OpenAIRE |
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