New Opportunities for Colorectal Cancer Diagnostics Using an Optical Cell Detection System Based on Dielectrophoresis

Autor:	K. V. Generalov, Vladimir N. Kruchinin, M. V. Kruchinina, Ya. I. Prudnikova, G. V. Shuvalov, Igor V. Minin, E. V. Kruchinina, I N Yakovina, N. A. Bannova, Oleg V. Minin, Andrey A. Gromov, V. M. Generalov
Rok vydání:	2019
Předmět:	010302 applied physics business.industry Colorectal cancer Cell Diagnostic accuracy Dielectrophoresis medicine.disease 01 natural sciences Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials 010309 optics medicine.anatomical_structure 0103 physical sciences Medicine In patient business Biomedical engineering
Zdroj:	Optics and Spectroscopy. 126:568-573
ISSN:	1562-6911 0030-400X
DOI:	10.1134/s0030400x19050163
Popis:	The possibilities of using electrical and viscoelastic parameters of erythrocytes in patients with colorectal cancer (CRC) of different stages were demonstrated using optical cell detection system based on the dielectrophoresis method. The deformation amplitude, portion of deformed cells, generalized viscosity, rigidity, equilibrium frequency position, and electrical conductivity were the most significant parameters for determining patients with CRC, as well as early and late stages, included in the created model of a riskometer for the disease diagnosis. The created diagnostic “panels” with a high diagnostic accuracy, sensitivity, and specificity allowed to one determine patients with CRC (specificity 0.91, sensitivity 0.96), as well as early and late stages of the disease (specificity 0.64, sensitivity 0.86).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::00f3ec75f7ba651a525f75634f6e0e80 https://doi.org/10.1134/s0030400x19050163 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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