Bis-naphthalimides. 2. Synthesis and biological activity of 5,6-acenaphthalimidoalkyl-1,8-naphthalimidoalkyl amines

Autor:	M J Pérez de Vega, Qian Xiao-Dong, M. Moran, J M Castellano, Gerhard Keilhauer, C A Romerdahl, M. F. Brana
Rok vydání:	1995
Předmět:	Pharmacology Chemistry Organic Chemistry Biological activity General Medicine Chromophore Chemical synthesis In vitro Naphthalimides chemistry.chemical_compound Drug Discovery Organic chemistry Amine gas treating Imide Cytotoxicity
Zdroj:	European Journal of Medicinal Chemistry. 30:235-239
ISSN:	0223-5234
Popis:	Summary A series of non-symmetric bis-naphthalimides bearing a conveniently substituted 1,8-naphthalimide and a 5,6-acenaphthalimide chromophore was synthesized and in vitro activities were determined. Although previous studies suggested that the presence of the acenaphthalimide system in the structure enhances aqueous solubility, we found that these compounds were no more soluble or cytotoxic than the homologous symmetric series.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::00f0e51fd3cf62f5d87da36e7e81e7da https://doi.org/10.1016/0223-5234(96)88230-4 Zobrazit plný text záznamu Full Text from ScienceDirect