Cholesterol synthesis and its regulation in acute myocardial infarction
| Autor: | Saroj P. Taskar, Neeta V. Shenvi |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cholesterol synthesis
medicine.medical_specialty business.industry Clinical Biochemistry Endogeny Increased Cholesterol Synthesis medicine.disease Endocrinology Internal medicine medicine lipids (amino acids peptides and proteins) In patient Myocardial infarction Reductase activity business Incubation |
| Zdroj: | Indian Journal of Clinical Biochemistry. 7:15-18 |
| ISSN: | 0974-0422 0970-1915 |
| DOI: | 10.1007/bf02867696 |
| Popis: | Cholesterol synthesis and its suppression by LDL was measured in freshly isolated leucocytes from patients with acute myocardial infarction and healthy controls. Cells incubated for different time intervals in lipoprotein-deficient serum exhibited increased cholesterol synthesis. The magnitude of this increase was far greater in leucocytes of hyperlipemic patients than in normolipemic patients. Addition of LDL to the incubation medium produced suppression of cholesterol synthesis. This reduction was less in hyperlipemic patients as compared to normolipemic patients. These observations may imply reduced suppression of HMG-CoA reductase activity with high endogenous cholesterol synthesis in patients suffering with acute myocardial infarction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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