Synthesis of substituted pyridine-2,4-dione nucleosides

Autor:	Eung K. Ryu, Jung Sup Park, Chang Ho Hwang, Joon Kwang Lee, Kun Hoe Chung, Jeong Hee Won
Rok vydání:	1992
Předmět:	chemistry.chemical_classification Base (chemistry) Pyrimidine Organic Chemistry Pharmacology toxicology Dichloroethane chemistry.chemical_compound chemistry Diphenyl carbonate Drug Discovery Pyridine Molecular Medicine Organic chemistry Lewis acids and bases
Zdroj:	Archives of Pharmacal Research. 15:87-90
ISSN:	1976-3786 0253-6269
DOI:	10.1007/bf02973990
Popis:	The syntheses of novel heterocyclic base modified pyrimidine nucleosides are described. 5,6-Dimethyl-4-hydroxy-3-methoxy-1-(β-D-ribofuranosyl)-2(1H)-pyridinone7 was synthesized by condensation of silylated 5,6-dimethyl-4-hydroxy-3-methoxy-2(1H)-pyridinone with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate in dichloroethane in the presence of Lewis acid followed by debenzoylation. The 2,2′-anhydro-5,6-dimethyl-2-hydroxy-3-methoxy-1-β-D-arabinofuranosyl-4-pyridinone8 was obtained from the reaction of the free ribonucleoside7 and diphenyl carbonate in DMF. None of these compounds showed any significant antiviral and antitumor activitiesin vitro tests.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::00d7e1f1a4f2776828dc2c1aa33cb880 https://doi.org/10.1007/bf02973990 Zobrazit plný text záznamu Full text from SpringerLink