Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D3

Autor:	S. Bajo, S. Molero, Consuelo Calle, N. Dávila, Begoña Maestro
Rok vydání:	2002
Předmět:	medicine.medical_specialty biology Chemistry Insulin medicine.medical_treatment Clinical Biochemistry Cell Biology General Medicine Transfection Carbohydrate metabolism Biochemistry IRS2 Wortmannin Insulin receptor chemistry.chemical_compound Endocrinology Internal medicine Insulin receptor substrate biology.protein medicine Phosphatidylinositol
Zdroj:	Cell Biochemistry and Function. 20:227-232
ISSN:	0263-6484
DOI:	10.1002/cbf.951
Popis:	Treatment with 10(-8) M 1,25-dihydroxyvitamin D(3) for 24 h causes transcriptional activation of the human insulin receptor gene in U-937 human promonocytic cells. The activation seems to potentiate the response to insulin in terms of glucose oxidation. Wortmannin, a phosphatidylinositol 3-kinase inhibitor, causes a greater inhibition of insulin-stimulated glucose oxidation in 1,25-dihydroxyvitamin D(3)-treated cells than in untreated cells. This suggests a stimulation of phosphatidylinositol 3-kinase activity by 1,25-dihydroxyvitamin D(3), which could mediate, at least in part, the potentiation of the insulin response.
Databáze:	OpenAIRE
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