Synthesis, Spectroscopic, Antibacterial, Antioxidant, DNA Binding and Cleavage, Molecular Docking Studies of Ni(II) and Cu(II) Complexes of S and N Donor Schiff Base Ligands

Autor:	S.P. Mydhili, Ramana Reddy Ch Venkata, B. Sireesha, S. Sreekanth
Rok vydání:	2021
Předmět:	Renewable Energy Sustainability and the Environment General Chemical Engineering General Earth and Planetary Sciences General Chemistry General Agricultural and Biological Sciences Biochemistry General Environmental Science
Zdroj:	Research Journal of Chemistry and Environment. 25:143-152
ISSN:	2278-4527 0972-0626
Popis:	Binary metal complexes of the ligands (L), H3FPT and H3FP4MT with Ni(II) and Cu(II) metal ions (M) were synthesized and characterized by different spectral and analytical techniques. Among these complexes, Ni(II)- H3FPT complex was found to be polymeric. The ligands and their complexes inhibited the growth of gram positive and gram negative bacterial strains to a moderate extent. The antioxidant nature of ligands and complexes was also established. Intercalative mode of binding of the complexes with calf thymus (CT) DNA was proposed from electronic absorption titrations, fluorescence quenching studies and viscosity measurements. The complexes showed hydrolytic cleavage of plasmid pBR322. Docking studies of metal complexes with DNA revealed that the complexes of H3FP4MT are more active than H3FPT.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::00cdaec2f1e65438df6231671705ab21 https://doi.org/10.25303/2511rjce143152 Zobrazit plný text záznamu