| Autor: |
Xi Cheng, Li-Yan Fu, Peng-Fei Lian, Jing-Jing Zhang, Yang-Ming Ou, Yong Ji, Guowei Huang, Pin-ting Yan, Li-Na An, Xu-Guang Gan, Meng-liu Yang, Xin-wen Li, Fei-Fei Hu, Yan Zeng, Ting-ting Duan, Yushan Chen, Qiong Wu, Bo Zhang, Zhen Wei, Ya-Fu Yu, Lin Li, Qing-Ming Wu, Yuan Tian, Ming-Jun Zou, Lang Xu, Guirong Cheng, Qian Liu, Yue-yi Wang, Xing-Xing Chen, Dan Liu, Xiao-Dan Wang, Lei Feng, Chong Chen, Heng Xu, Jin Qian, Xi-Fei Yang, Jinquan Li |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.3786709 |
| Popis: |
Background: The prevalence of dementia in China, particularly in rural areas, is consistently increasing. Researchers have built upon the evidence that many dementia cases can be prevented, but most data came from high-income countries. Methods: A cross-sectional survey, named the China Multicentre Dementia Survey, was conducted. Face-to-face interviews, neuropsychological and clinical assessments were performed. Consensus dementia diagnoses were reached. Weighted population-attributable fractions (PAFs) were conducted for eight risk factors (six classical and two novels) in selected rural and urban areas, to identify potential dementia prevention targets. Findings: Overall, 17,589 respondents aged ≥ 65 years completed the survey between April 2018 and November 2020, 55.6% of whom were rural residents. The age and sex adjusted prevalence for all-cause dementia was 9.11% (95% CI 8.96–9.26), 5.19% (5.07–5.31), and 11.98% (11.8–12.15) in the whole, urban, and rural areas of China, respectively. And the overall weighted PAF of eight potentially modifiable risk factors was 53.72% (95% CI 52.73–54.71), 50.64% (49.4–51.89), and 56.54% (55.62–57.46), respectively. These eight risk factors’ profiles differed between rural and urban areas. Lower childhood education (PAF: 13.92%) and physical inactivity (16.99%) was the primary risk factor in rural and urban, respectively. Interpretation: The dementia prevalence has been increased in China over the past 5 years. The dementia prevention potential in China is greater than that reported worldwide. Resident-specific dementia prevention strategies should be developed. Funding: This work was financially supported by grants from the National Natural Science Foundation of China. Declaration of Interest: We declare no competing interests Ethical Approval: The protocol for this study was reviewed and approved by the Medical Ethics Committee at Wuhan University of Science and Technology (ID: 201845), and the Medical Ethics Committee at Tianjin Huanhu Hospital (ID: 2019-40). Please find the detailed ethical report from supplementary files. We confirm that the study was conducted in accordance with Helsinki Declaration as revised in 2013. We state that written informed consent was obtained from the participants of the study (and the relevant document(s) will be provided when requested by the journal). This study does not involving minor subjects/children/infants. We declare that personal details of patients in any part of the paper and in any supplementary materials (including illustrations) have been removed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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