Misidentification of unstable, low oxygen affinity hemoglobin variant
| Autor: | Sridevi Devaraj, Xinpu Chen, Beverley Vispo, Joanna Jung, Jing Cao, Emily Garnett, M. Tarek Elghetany |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Hemolytic anemia medicine.medical_specialty Clinical Biochemistry Delayed diagnosis Biochemistry Gastroenterology 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine medicine Unstable hemoglobin Low oxygen business.industry Biochemistry (medical) Hemoglobin variants General Medicine Hypoxia (medical) medicine.disease 030104 developmental biology Hemoglobinopathy 030220 oncology & carcinogenesis Hemoglobin medicine.symptom business |
| Zdroj: | Clinica Chimica Acta. 509:177-179 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2020.06.023 |
| Popis: | Background We present a case of Hemoglobin (Hgb) Louisville in a 6-y old girl presenting with hypoxia and mild hemolytic anemia. Methods Hgb Louisville is a rare, unstable hemoglobin variant with low oxygen affinity, but initial workup of this case using widely-available hemoglobin fractionation methods was unable to differentiate this variant from normal hemoglobins. Results This resulted in a delayed diagnosis. Conclusion This case highlights the limitations of routine hemoglobin fractionation methods for correct diagnosis of hemoglobin variants, and subsequent impact on patient care and management. |
| Databáze: | OpenAIRE |
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