Case-control study of patients with essential tremor in Latvia

Autor:	E. Vitols, Eriks Jankevics, Ilze Radovica, Ligita Smeltere, Inna Inashkina
Rok vydání:	2008
Předmět:	Genetics medicine.medical_specialty Essential tremor business.industry Case-control study medicine.disease Gastroenterology Neurology Polymorphism (computer science) Internal medicine Cohort Genotype medicine Microsatellite Neurology (clinical) Allele business Allele frequency
Zdroj:	European Journal of Neurology. 15:988-990
ISSN:	1468-1331 1351-5101
DOI:	10.1111/j.1468-1331.2008.02225.x
Popis:	Background: Essential tremor (ET) is the most prevalent inherited movement disorder. ET has been mapped on chromosomes 2 and 3, but causative genes are not known. Methods: We genotyped 16 microsatellite markers in a case–control cohort consisting of 104 patients and 116 controls. Results: No significant difference between allele frequencies was found. The highest difference of frequencies was found in allele 171 of the marker D2S220 (OR 0.13, 95% CI 0.02–1.03, P = 0.05). In addition, we investigated the distribution of suspected disease gene DRD3 Ser9Gly polymorphism in the same patients and controls. Conclusion: There was not a significant difference in genotypic distribution between disease group and control subjects (χ2 = 2.8, P = 0.25).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::00c9d41e7ca1cca84cecfdc470461793 https://doi.org/10.1111/j.1468-1331.2008.02225.x Zobrazit plný text záznamu Plný text