Tipurile de vase asociate tumorilor GIST influenteaza eficienta terapiei antivasculare cu inhibitori de receptor tirozin-kinazic
| Autor: | Ion Barbu, Cristian Furau, Bogdan Totolici, Alexandru Dumnici, Diana Gheorghiu, Dragos Botezatu, Nicolae Gheorghiu, Mihai Dimitriu, Eftimie Miutescu, Ada Maria Codreanu, Bogdan Socea, Andrei Dan Korodi, Gheorghe Furau |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Engineering
Process equipment business.industry Materials Science (miscellaneous) Process Chemistry and Technology Metallurgy General Engineering General Chemistry General Medicine General Biochemistry Genetics and Molecular Biology Petrochemistry Materials Chemistry General Pharmacology Toxicology and Pharmaceutics business |
| Zdroj: | Revista de Chimie. 70:3250-3253 |
| ISSN: | 2668-8212 0034-7752 |
| DOI: | 10.37358/rc.19.9.7528 |
| Popis: | Gastrointestinal stromal tumors (GIST�sare the most common mesenchymal neoplasms of the alimentary tract. Angiogenesis is an essential condition in the growth and development of tumors, especially in the case of GISTs due to their particular behavior. The aggressive behavior depends on the size and site of the tumor in close relationship with the intratumoral vascular development. The purpose of this study is to investigate, using immunohistochemical stainings, the types of intratumoral vessels in GIST�s, knowing the interrelation between the tumor angiogenesis and the response to the targeted antivascular therapy, influencing directly the prognosis. In our research, in all 37 cases the most numerous vessels were the immature and intermediate ones, signaling an increased angiogenic activity. The perivascular cell free vessels are the most sensitive at antivascular therapy with tyrosine kinase receptor inhibitors, providing a good response and prognosis to the treatment. Immature vessels evaluation especially, could be a an important sign in assessment of the effectiveness of antivascular therapy in GIST. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|