Le sulfure d’hydrogène : une thérapeutique d’avenir dans la neuroprotection post-arrêt cardiorespiratoire ?
| Autor: | Pierre Leroy, S. Le Tacon, Ariane Boudier, Claude Vigneron, H. Sayouri |
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| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
biology business.industry Pharmaceutical Science Context (language use) Oxidative phosphorylation Hypothermia Neuroprotection Potassium channel 3. Good health chemistry.chemical_compound chemistry Apoptosis biology.protein Medicine Cytochrome c oxidase medicine.symptom business Adenosine triphosphate |
| Zdroj: | Annales Pharmaceutiques Françaises. 73:401-410 |
| ISSN: | 0003-4509 |
| DOI: | 10.1016/j.pharma.2015.04.005 |
| Popis: | Each year, in France, the number of cardiac arrests is evaluated between 30,000 to 50,000. When a patient survives, he undergoes a post-resuscitation syndrome which can aggravate the injuries and for which nowadays, no medication is available. In some kinds of cardiac arrest, a hypothermia protocol can be applied with a need for monitoring because of the appearance of side effects. In this context, hydrogen sulfide, which is a gasotransmitter with numerous physiological and pharmacological properties, may be interesting. Indeed, its use could protect against oxidative, inflammatory and apoptotic troubles induced by the post-resuscitation syndrome. The implied biochemical mechanisms are adenosine triphosphate potassium channels activation and cytochrome c oxidase inhibition. This molecule can also induce a suspended animation state characterized by a metabolism decrease, which could give a delay for physicians to start a therapeutic monitoring. Thus, in spite of a modest and sometimes contradictory literature, this compound could become the first neuroprotective molecule in cardiac arrest. |
| Databáze: | OpenAIRE |
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