Effect of phosphate on the biosynthesis of nourseothricin by Streptomyces noursei JA 3890b

Autor:	H. H. Grosse, H. Bocker, G. Haubold, M. Menner, J. H. Ozegowski, P. J. Müller
Rok vydání:	2007
Předmět:	biology Streptomycetaceae General Medicine biology.organism_classification Phosphate Applied Microbiology and Biotechnology chemistry.chemical_compound Streptomyces noursei Biosynthesis chemistry Biochemistry Genetics Nourseothricin Fermentation Actinomycetales Secondary metabolism
Zdroj:	Zeitschrift für allgemeine Mikrobiologie. 24:555-564
ISSN:	1521-4028 0044-2208
Popis:	The results present evidence for the important role of phosphate-mediated regulation of the nourseothricin biosynthesis by the processes of phosphate limitation and release of phosphate. Also, higher initial concentrations of phosphate were found to have a strong inhibitory effect on the biosynthesis of nourseothricin. It is concluded that the initial phosphate concentration was the primary target for the biometrical optimization of the fermentation medium. The presence of zinc ions neutralized the negative effect of high initial concentrations of phosphate which was also strongly influenced by the regime of sterilization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::00b5c8ebd90d3fd1b3924f647c2481dd https://doi.org/10.1002/jobm.19840240812 Zobrazit plný text záznamu Plný text