Hemolymph coagulation and phenoloxidase in larvae
| Autor: | Gawa Bidla, Malin Lindgren, Mitchell S. Dushay, Ulrich Theopold |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Hemolymph coagulation
animal structures Innate immune system biology media_common.quotation_subject fungi Immunology Insect biochemical phenomena metabolism and nutrition biology.organism_classification Cell biology Galleria mellonella Immune system Hemolymph Drosophila melanogaster Drosophila Developmental Biology media_common |
| Zdroj: | Developmental & Comparative Immunology. 29:669-679 |
| ISSN: | 0145-305X |
| Popis: | Hemolymph coagulation is a first response to wounding in insects. Although studies have been performed in large-bodied insects such as the moth Galleria mellonella, less is known about clotting in Drosophila melanogaster, the insect most useful for genetic and molecular analyses of innate immunity. Here we show the similarities between clots in Drosophila and Galleria by light- and electron microscopy. Phenoloxidase changes the Drosophila clot's physical properties through cross-linking and melanization, but it is not necessary for preliminary soft clot formation. Bacteria associate with the clot, but this alone does not necessarily kill them. The stage is now set for rapid advances in our understanding of insect hemolymph coagulation, its roles in immune defense and wound healing, and for a more comprehensive grasp of the insect immune system in general. |
| Databáze: | OpenAIRE |
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