Specificity and mechanism of stimulation of adenylate deaminase activity by serotonin

Autor:	Suvorov Nn, Gorkin Vz, L. G. Repyakh, L. I. Gridneva
Rok vydání:	1975
Předmět:	AMP deaminase Stimulation General Medicine Biology Cycloheximide Mitochondrion General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Biochemistry chemistry In vivo Protein biosynthesis heterocyclic compounds Serotonin Phosphodiesterase inhibitor
Zdroj:	Bulletin of Experimental Biology and Medicine. 80:1181-1183
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00833153
Popis:	The adenylate deaminase activity of the mitochondrial fraction of rat liver was stimulated in vivo not only by serotonin (5-HT) or other biogenic and synthetic indolylalkylamines, but also by phenyl- and imidazolealkylamines. 5-HT also stimulated adenylate deaminase activity of the liver mitochondria of CBA mice. Actinomycin D or cycloheximide, inhibitors of protein biosynthesis, prevented the stimulation of adenylate deaminase activity by 5-HT. Theophylline, a phosphodiesterase inhibitor, gave a similar effect only in the presence of a high degree of stimulation of adenylate deaminase activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::00a8dc68340503b130ac8df335cbfd0a https://doi.org/10.1007/bf00833153 Zobrazit plný text záznamu Full text from SpringerLink