Lipase-Catalyzed Enantioselective Hydrolysis of Bis(acyloxymethyl) 1,4-Dihydro-3,5-pyridinedicarboxylates Leading to Optically Active Medicines

Autor:	Hirose Yoshihiko, Yoshiyasu Terao, Yukiyoshi Yamazaki, K. Maruyama, Hirosato Ebiike, Y. Kurono, Kazuo Achiwa, I. Sasaki, Kariya Kinya
Rok vydání:	1997
Předmět:	Carboxylic Ester Hydrolases biology Chemistry Organic solvent Triacylglycerol lipase Enantioselective synthesis General Chemistry General Medicine Optically active Catalysis Hydrolysis Drug Discovery biology.protein Organic chemistry Lipase
Zdroj:	Chemical and Pharmaceutical Bulletin. 45:863-868
ISSN:	1347-5223 0009-2363
Popis:	Chiral 4-aryl-1, 4-dihydro-2, 6-dimethyl-3, 5-pyridinedicarboxylates and 1, 4-dihydro-2, 4, 6-trimethyl-3, 5-pyridinedicarboxylate have been obtained in 80-99%ee by lipase-catalyzed hydrolysis of bis(acyloxymethyl) 1, 4-dihydro-3, 5-pyridinedicarboxylate in an H2O/organic solvent system. These chiral dihydropyridines were readily converted into chiral drugs, such as nicardipine, felodipine and PCA 4248.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::00a89b3d578d7ce83ff7f7ae17f318c2 https://doi.org/10.1248/cpb.45.863 Zobrazit plný text záznamu