Lipase-Catalyzed Enantioselective Hydrolysis of Bis(acyloxymethyl) 1,4-Dihydro-3,5-pyridinedicarboxylates Leading to Optically Active Medicines
Autor: | Hirose Yoshihiko, Yoshiyasu Terao, Yukiyoshi Yamazaki, K. Maruyama, Hirosato Ebiike, Y. Kurono, Kazuo Achiwa, I. Sasaki, Kariya Kinya |
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Rok vydání: | 1997 |
Předmět: | |
Zdroj: | Chemical and Pharmaceutical Bulletin. 45:863-868 |
ISSN: | 1347-5223 0009-2363 |
Popis: | Chiral 4-aryl-1, 4-dihydro-2, 6-dimethyl-3, 5-pyridinedicarboxylates and 1, 4-dihydro-2, 4, 6-trimethyl-3, 5-pyridinedicarboxylate have been obtained in 80-99%ee by lipase-catalyzed hydrolysis of bis(acyloxymethyl) 1, 4-dihydro-3, 5-pyridinedicarboxylate in an H2O/organic solvent system. These chiral dihydropyridines were readily converted into chiral drugs, such as nicardipine, felodipine and PCA 4248. |
Databáze: | OpenAIRE |
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