| Popis: |
Colorectal cancer (CRC) is a third most common malignant neoplasm arising from the lining of colon and rectum of the large intestine. The molecular mechanisms provide some fundamental effects and activities of molecules as chemopreventive, anti-inflammatory, and antioxidative agents in CRC. The expressions and regulation of COX-2, HER-2, Oct4, Sox2, p53, MDR1/P-glycoprotein, CXCR4, VEGF-C, etc. are important to understand the anti-inflammatory molecular mechanisms and inhibitory effect on cell growth and in induction of apoptosis in colorectal cancer. Nonsteroidal anti-inflammatory drugs (NSAIDs) and several drug inhibitors can act against colorectal tumorigenesis. The present literature and experimentation provide the precise information on anti-inflammatory molecular mechanisms that regulate apoptosis in colorectal cancer cells and on proliferation and on induction of apoptosis by nonsteroidal anti-inflammatory inhibitors as transport molecules in colorectal cancer cells. The gene superfamilies that are involved in the transport of drugs are the solute carrier (SLC) family and the ATP-binding cassette (ABC) family. The effects of selective COX-2 inhibitors (COXIBs) and nonsteroidal anti-inflammatory drugs (NSAIDs) may be the most promising chemopreventive agents for CRC prevention and treatment. |
