Partitioning of Cephalexin in Aqueous Two-Phase Systems Containing Poly(ethylene glycol) and Sodium Citrate Salt at Different Temperatures

Autor:	Gholamreza Pazuki, Shahla Shahriari, Sara Ghayour Doozandeh
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Aqueous solution Molar mass General Chemical Engineering Inorganic chemistry Salt (chemistry) General Chemistry Polymer Partition coefficient chemistry.chemical_compound stomatognathic system chemistry Sodium citrate Ethylene glycol Mass fraction
Zdroj:	Journal of Chemical & Engineering Data. 57:256-262
ISSN:	1520-5134 0021-9568
Popis:	In this study, the partitioning process of cephalexin antibiotic in aqueous two-phase systems (ATPS's) containing poly(ethylene glycol) (PEG) with molar masses of (1500 and 6000) g·mol–1 and sodium citrate salt has been measured. The experimental partition coefficients were measured at three temperatures: (298, 303, and 308) K. The effects of temperature, polymer mass fraction, polymer molar mass, and salt mass fraction on the experimental partition coefficient of cephalexin were also studied. The results showed that the polymer molar mass has a large effect on the partition coefficient and the temperature influence is almost negligible. The experimental data of the partition coefficients of cephalexin in polymer–salt ATPS's were correlated using the equation proposed by Diamond–Hsu.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::009a82017d6bc5a1a889ed5ca2b96c8d https://doi.org/10.1021/je201033f Zobrazit plný text záznamu