Sulfhydryl-Containing Agents and the Effects of Ionizing Radiations
| Autor: | E.P. Cronkite, W.H. Chapman, F. W. Chambers, C.R. Sipe, Elitzholtz Dc |
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| Rok vydání: | 1950 |
| Předmět: | |
| Zdroj: | Radiology. 55:865-873 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/55.6.865 |
| Popis: | Total body exposure to ionizing radiations results in widespread cellular damage which is manifest by the promptly ensuing “toxemia” known as radiation illness. The cellular damage has in the past been considered largely due to (a) protein denaturation and (b) the formation of “toxic products.” These concepts resulted in various forms of symptomatic and replacement therapy for radiation illness. Recent reports have stimulated new investigative and therapeutic endeavor in this field by calling attention to the effects produced by the ionization products of irradiated water on the sulfhydryl enzyme systems. These ionization products of irradiated water (OH, O2H and H2O2, etc.) (1, 2) are active oxidizing agents and have been shown to inhibit the sulfhydryl-containing enzymes (3–6), the degree of inhibition being directly related to the dosage of radiation. High doses of radiation produce irreversible enzymatic inhibition presumably by protein denaturation, whereas the inhibition from low doses may be revers... |
| Databáze: | OpenAIRE |
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