Acute phase proteins as markers of systemic illness in acute diarrhoea
| Autor: | Rose R. Kingamkono, A. E. Msengi, Andrew Tomkins, Jonathan C. Darling, SM Filteau, Jesse Kitundu |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Population Acute-phase protein General Medicine Predictive value Gastroenterology Confidence interval Surgery Diarrhea El Niño Internal medicine Pediatrics Perinatology and Child Health medicine Serum amyloid A medicine.symptom education business Acute diarrhoea |
| Zdroj: | Acta Paediatrica. 88:259-264 |
| ISSN: | 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1999.tb01093.x |
| Popis: | 57 Tanzanian children aged 6-25 months hospitalized with acute diarrhea were grouped according to whether there was clinical evidence of systemic infection (SI) (n = 35) or not (n = 22). Serum acute phase proteins were measured in samples taken within 48 hours of admission. Means for C-reactive protein (CRP) and serum amyloid A (SAA) were significantly higher in children with SI compared to those without (geometric means (95% confidence interval); CRP mg/l: 22.1 (13.6-35.5) vs. 7.4 (4.4-12.4); SAA mg/l: 12.2 (6.8-22.1) vs. 4.9 (2.5-9.7)). Levels of alpha1-acid glycoprotein were similar in both groups (1.16 g/l (0.95-1.43) vs. 1.04 g/l (0.83-1.29) respectively). CRP >or= 30 mg/l had a positive predictive value of 95% and specificity of 96% for correctly identifying SI but a low sensitivity (51%) and negative predictive value (55%). Clinical outcome of diarrhea was worse in children with SI: more needed intravenous fluids (23% vs. 5%) the duration of diarrhea was longer (59.4 vs. 34.2 h) and mortality was higher (6% vs. 0%). APPs were not found to be useful markers of systemic illness in acute diarrhea in this population. (authors) |
| Databáze: | OpenAIRE |
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