Autor:	Otto Dungan, Shawn Dormann, Sandra Fernandes-Denney, Brian Duffy, Daniel Effiong, William Kerr, John Chisholm
Rok vydání:	2021
Popis:	A new synthetic route to the SHIP1 agonist AQX-1125 has been developed. This sequence utilizes a hydroxy-acid intermediate which allows for ready differentiation of the C6 and C7 positions. The role of the C17 alkene in the biological activity of the system is also investigated, and this functional group is not required for SHIP1 agonist activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0087ac4d0707b3956be4e32a9444e5c2 https://doi.org/10.26434/chemrxiv-2021-vdnql Zobrazit plný text záznamu