Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats

Autor:	Kuwa K, S Sakamoto, H Kudo
Rok vydání:	1996
Předmět:	Cancer Research Thymidine kinase activity Cancer Tumor M2-PK General Medicine Cell cycle Biology medicine.disease 1 2-Dimethylhydrazine chemistry.chemical_compound Oncology chemistry Thymidine kinase Cancer research medicine Nucleotide salvage Tumor marker
Zdroj:	Oncology Reports.
ISSN:	1791-2431 1021-335X
Popis:	Thymidine kinase is the key enzyme in salvage pathway for pyrimidine nucleotide synthesis. High activities of thymidine kinase have been found in rapidly proliferating normal, neoplastic tissues and sera from patients with various diseases including lymphoma, leukemias and small cell lung cancer. We investigated the serum thymidine kinase activities and the colorectal carcinomas in rats treated with 1,2-dimethylhydrazine. The positive correlations between serum thymidine kinase activities and numbers of total and large tumors were observed. These findings suggest the measurement of serum thymidine kinase activity may be clinically valuable in an early stage of the colonic carcinogenesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::00847dd70efed1c19c7f95c33f4f2862 https://doi.org/10.3892/or.3.1.15 Zobrazit plný text záznamu