| Popis: |
Syntheses of novel [{(3-dialkoxy-phosphoryl)-(substituted-phenyl-methyl)-2-oxo-2-phenyl-2,3-dihydro-2λ5–benzo [1,3,2] diazaphosphol-1-yl}-(substituted-phenyl)-methyl]-phosphonic acid diethyl/dimethyl esters (3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j) were conveniently accomplished by cyclocondensation of [(2-{(dimethoxy-phosphoryl)-phenyl-methyl)-amino}-phenyl amino)-phenyl-methyl]phosphonic acid diethyl/dimethyl esters (2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j) with phenyl phosphonic dichloride in dry toluene in the presence of triethylamine at 40°C. The title compounds were characterized by physicospectral techniques. All the synthesized compounds were found to possess antimicrobial properties. J. Heterocyclic Chem., 2011. |
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