NaNO2/I2 as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides
| Autor: | Dinesh S. Barak, Sanjay Batra, Dipak J. Dahatonde, Sushobhan Mukhopadhyay |
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| Rok vydání: | 2019 |
| Předmět: |
010405 organic chemistry
Organic Chemistry Nitrosylation Intramolecular cyclization chemistry.chemical_element Halide 010402 general chemistry Iodine 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Reagent Drug Discovery Sodium nitrite |
| Zdroj: | Tetrahedron Letters. 60:248-251 |
| ISSN: | 0040-4039 |
| Popis: | An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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