Comprehensive Review on Methadone-Induced QT Prolongation and Torsades
| Autor: | Mohammad Al Madani, Timir K. Paul, Jennifer Treece, Steven J. Baumrucker, George El Khoury, James E Martin, Christopher A Neglia, Ola Khraisha |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
business.industry Analgesic Chronic pain Torsades de pointes 030204 cardiovascular system & hematology medicine.disease QT interval 03 medical and health sciences 0302 clinical medicine Opioid Morphine Medicine Pharmacology (medical) 030212 general & internal medicine business Depression (differential diagnoses) Methadone medicine.drug |
| Zdroj: | Journal of Pharmacology and Pharmacotherapeutics. 9:66-75 |
| ISSN: | 0976-5018 0976-500X |
| DOI: | 10.4103/jpp.jpp_163_17 |
| Popis: | An alternative analgesic to morphine is methadone, which is used to control chronic pain and is used in opioid rehabilitation treatment programs due to methadone having a long half-life and being relatively inexpensive as compared to extended-release forms of morphine. Despite its benefits, methadone accumulates in adipose tissue due to being lipophilic, binds strongly to plasma proteins, and is metabolized in the liver by the cytochrome P450 system causing methadone levels to be variable and subject to influence according to the individual body compositions and concurrent use of cytochrome P450 inhibitors. In addition to methadone being able to cause both respiratory and central nervous system depression, methadone can also prolong the QT interval and cause potentially life-threatening arrhythmias including torsades de pointes. The susceptibility of unintentional overdosing of methadone due to its varied pharmacologic properties and potentially fatal induction of arrhythmias may cause the risks of methadone use to outweigh its benefits and therefore must be closely monitored. |
| Databáze: | OpenAIRE |
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